Product Liability Update: 9/4/2010

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Life threatening skin reaction asscoiated with prescription and OTC medication

Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but serious, often debilitating disorders affecting the skin and mucous membranes. In most cases, SJS is the result of a severe allergic reaction to a medication, particularly anti-inflammatory medications (NSAIDs), anticonvulsants such as Dilantin® and Lamictal®, and antibiotic drugs like Allopurinol.

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SJS and TEN can affect both men and women of all ages, as well as children. Treatment, which usually requires hospitalization, can take up to several months depending on the severity of the reaction. Signs and symptoms of SJS and TEN may include the following:

• A painful red or purple rash on the skin that spreads and blisters
• Blisters in the mouth, eyes, ears, nose, throat or genital area
• Persistent fever
• Flu-like symptoms (fever, headache, cough, body ache)
• Facial swelling, hives
• Swelling of the eyelids, red eyes, Conjunctivitis, corneal blisters and perforation
• Peeling and shedding of the skin
• Recent history of having taken a prescription or over-the-counter medication

Medications Associated with SJS

Any drug has the potential to cause an SJS or TEN skin reaction. The most commonly implicated drugs are anti-convulsants, antibiotics, and anti-inflammatory medications, including:

• Allopurinol - a drug used for treating gout caused by excessive levels of uric acid in the blood (hyperuricemia).
• Dilantin (phenytoin) - a prescription anti-seizure medication used in the treatment of epilepsy.
• Lamictal (lamotrigine) - an anti-epileptic medication used to treat seizures.

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